![]() An additional, more modest, effect along the distal nephron, however, is also observed. In the kidney, carbonic anhydrase inhibitors (CAIs) act primarily on proximal tubule cells to inhibit bicarbonate absorption ( Fig. The major sites of action of diuretics and the fraction of filtered Na + reabsorbed at the corresponding nephron segments are summarized in Figure 46-1 .įIGURE 46-1 Nephron diagram shows the primary sites of diuretic action and the approximate fraction of filtered sodium reabsorbed at each. More extensive and historical references appeared in the last edition the interested reader is referred to the seventh edition, for more detailed references. Diuretics have been reviewed extensively. Other chapters discuss the treatment of hypertension by diuretic drugs ( Chapter 45 ), diuretic-induced changes in potassium excretion ( Chapter 15 ), acid-base disturbances ( Chapter 14 ), divalent cation excretion and nephrolithiasis ( Chapters 16 and 37 ), the syndrome of inappropriate antidiuretic hormone (SIADH) secretion ( Chapter 13 ), and acute kidney injury (AKI Chapter 29 ). The chapter concludes with a discussion of the practical use of diuretics in the treatment of specific clinical conditions. This provides a framework for the design of strategies to maximize the desired actions while minimizing the unwanted effects. Diuretic resistance, its management, and the major adverse effects of therapy are discussed. ![]() Loop and thiazides are the most widely used diuretics, and the physiologic adaptations to their prolonged use are described. The effects of disease on diuretic kinetics are discussed because this predicts the required dosage modifications. The major transport targets for diuretic drugs have been defined and their genes cloned. ![]() This chapter reviews the mechanisms of action, physiologic adaptation, adverse effects, and clinical uses of diuretics. Humoral and Neuronal Modulators of the Response to Diuretics, 1657įluid and Electrolyte Abnormalities, 1659 Thiazides and Thiazide-like Diuretics (Distal Convoluted Tubule Diuretics), 1652 The gift honors Wedge’s fondness for Purchase-a place he credits for helping to build the foundation for his enormously successful career.Brenner and Rector's The Kidney, 8th ed. Their generous donation is helping to fund the renovation of the film sound stage in the music building. He recently completed his first live action/hybrid film Monster Trucks, released in 2017.Ī long-time supporter of the college, Wedge and his wife, Jeanne Markel ’81 (visual arts), donated a major gift to the School of Film and Media Studies in 2017. He directed Epic, which was released in 2013. Seuss’ Horton Hears a Who!, and the global hits Rio, Ice Age: Dawn of the Dinosaurs, and Ice Age: Continental Drift. He was executive producer of Ice Age: The Meltdown, Dr. Wedge went on to direct Blue Sky’s first two computer-animated feature films, Ice Age (nominated for an Oscar® in the category Best Animated Feature Film) and Robots. He wrote and directed Blue Sky’s first film, Bunny, which won more than 25 international awards for animation excellence, including an Academy Award for Best Animated Short Film in 1998. Wedge also holds an MA in Computer Graphics/Art Education from Ohio State University’s Advanced Computing Center for the Arts and Design. He started his career in computer animation at MAGI/Synthavision, where he animated key sequences for the 1982 cult classic, TRON. As co-founder and vice president of creative development of Blue Sky Studios, FOX, Wedge is the driving force behind the rise of Blue Sky Studio’s prominence as one of the most respected computer animation studios in the world. Chris Wedge ’81 was honored by Purchase College with a Distinguished Alumni Award in 2009. ![]()
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